Possible reply to "Can this be real?" Crossword Clue

Looking for the answer to “Possible reply to "Can this be real?"” from the Universal crossword of December 17, 2024? It has 4 letters. Flip the tiles one at a time, try a hint first, or look through the rest of that puzzle.

Crossword answer

UNIVERSAL, DECEMBER 17, 2024

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Hints

Three clues to the answer, gentle first. Open one at a time.

Hint 1 Meaning

Hint 2 Anagram

Hint 3 Another clue

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Questions

What is the answer to “Possible reply to "Can this be real?"”?

ITIS, 4 letters.

When was “Possible reply to "Can this be real?"” last seen in a crossword?

In the Universal crossword of December 17, 2024.

How many letters does the answer have?

4 letters, starting with I.