gis and sig tie for the highest Scrabble score from gis at 4 points. The top 5 of 5 words are shown here, with the full list organized by length below.
There are 2 three-letter words hiding in gis: one comes from rearranging its letters, and gis itself is already a playable word with no unscrambling required. No common everyday answer stands out among these three-letter results, so let the score decide: the highest-scoring words are gis and sig, each worth 4 points in Scrabble.
gis is in the NWL, the official Scrabble word list for North America, but not in the Words With Friends dictionary, so it plays in Scrabble only.
Dictionaries record four senses for gis. Scrabble and Words With Friends score tiles and not meanings, so every sense below is worth the same 4 points on a Scrabble board:
gis is one of two three-letter words the same letters produce. No arrangement of the same tiles scores higher in Scrabble, so playing gis unchanged also takes the maximum points these letters offer.
The highest-scoring plays from these letters are gis and sig, worth 4 points in Scrabble, and nothing else built from gis earns more points in Scrabble. Words With Friends prices the same letters differently, so the top of the list changes on a Words With Friends board. Both scores count tile values only and exclude premium squares.
The letters in gis produce 5 valid words in the Scrabble and Words With Friends dictionaries. The word count by length is: 2 three-letter words and 3 two-letter words.