mayfly needs no unscrambling at all — the six-letter word is already the strongest play its own letters allow, banking 17 points in Scrabble as it stands. In all, 21 valid words come out of this rack, grouped by length below and checked for Words With Friends as well as Scrabble.
mayfly is the highest-scoring word from mayfly, worth 17 points in Scrabble. The top 10 of 21 words are shown here, with the full list organized by length below.
Only one six-letter word uses the letters in mayfly — and it is mayfly itself. No unscrambling is needed: the word is already playable as written, worth 17 points in Scrabble.
Unscrambling mayfly produces exactly one five-letter word: flamy. It is not one of the common answers — a genuine unscrambler find — and it banks 13 points in Scrabble.
Swap a single tile in mayfly and you get a different six-letter rack with its own word list. None of these appear in the results above — they share 5 of the 6 letters, not all of them.
mayfly is in the NWL, the official Scrabble word list for North America, and in the Words With Friends dictionary, so it's playable exactly as it stands and needs no unscrambling.
Both totals match, because every tile in mayfly carries the same value on a Scrabble board and on a Words With Friends board.
Dictionaries record one sense for mayfly. Scrabble and Words With Friends score tiles and not meanings, so every sense below is worth the same 17 points on a Scrabble board:
mayfly is the only six-letter word the same letters produce. No arrangement of the same tiles scores higher in Scrabble, so playing mayfly unchanged also takes the maximum points these letters offer.
The highest-scoring play from these letters is mayfly, worth 17 points in Scrabble, and no other word from mayfly earns more points in Scrabble. Words With Friends prices the same letters differently, so the top of the list changes on a Words With Friends board. Both scores count tile values only and exclude premium squares.
The letters in mayfly produce 21 valid words in the Scrabble and Words With Friends dictionaries. The word count by length is: 1 six-letter word, 1 five-letter word, 3 four-letter words, 8 three-letter words and 8 two-letter words.