rune needs no unscrambling at all — the four-letter word is already the strongest play its own letters allow, banking 4 points in Scrabble as it stands. In all, 11 valid words come out of this rack, grouped by length below and checked for Words With Friends as well as Scrabble.
rune is the highest-scoring word from rune, worth 4 points in Scrabble. The top 10 of 11 words are shown here, with the full list organized by length below.
Only one four-letter word uses the letters in rune — and it is rune itself. No unscrambling is needed: the word is already playable as written, worth 4 points in Scrabble.
There are 6 two-letter words that can be made by unscrambling the letters in rune. No common everyday answer stands out among these two-letter results, so let the score decide: the highest-scoring words are en, er, ne and 3 more, each worth 2 points in Scrabble.
Swap a single tile in rune and you get a different four-letter rack with its own word list. None of these appear in the results above — they share 3 of the 4 letters, not all of them.
rune is in the NWL, the official Scrabble word list for North America, and in the Words With Friends dictionary, so it's playable exactly as it stands and needs no unscrambling.
The 2-point gap between the two totals comes from the tile values themselves: Scrabble and Words With Friends price the same letters differently.
Dictionaries record one sense for rune. Scrabble and Words With Friends score tiles and not meanings, so every sense below is worth the same 4 points on a Scrabble board:
rune is the only four-letter word the same letters produce. No arrangement of the same tiles scores higher in Scrabble, so playing rune unchanged also takes the maximum points these letters offer.
The highest-scoring play from these letters is rune, worth 4 points in Scrabble, and no other word from rune earns more points in Scrabble. Words With Friends prices the same letters differently, so the top of the list changes on a Words With Friends board. Both scores count tile values only and exclude premium squares.
The letters in rune produce 11 valid words in the Scrabble and Words With Friends dictionaries. The word count by length is: 1 four-letter word, 4 three-letter words and 6 two-letter words.