kiwi and wiki tie for the highest Scrabble score from wiki at 11 points. The top 3 of 3 words are shown here, with the full list organized by length below.
There are 2 four-letter words hiding in wiki: one comes from rearranging its letters, and wiki itself is already a playable word with no unscrambling required. No common everyday answer stands out among these four-letter results, so let the score decide: the highest-scoring words are kiwi and wiki, each worth 11 points in Scrabble.
Unscrambling wiki produces exactly one two-letter word: ki. It is not one of the common answers — a genuine unscrambler find — and it banks 6 points in Scrabble.
Swap a single tile in wiki and you get a different four-letter rack with its own word list. None of these appear in the results above — they share 3 of the 4 letters, not all of them.
wiki is in the NWL, the official Scrabble word list for North America, and in the Words With Friends dictionary, so it's playable exactly as it stands and needs no unscrambling.
Both totals match, because every tile in wiki carries the same value on a Scrabble board and on a Words With Friends board.
wiki is one of two four-letter words the same letters produce. No arrangement of the same tiles scores higher in Scrabble, so playing wiki unchanged also takes the maximum points these letters offer.
The highest-scoring plays from these letters are kiwi and wiki, worth 11 points in Scrabble, and nothing else built from wiki earns more points in Scrabble. Words With Friends prices the same letters differently, so the top of the list changes on a Words With Friends board. Both scores count tile values only and exclude premium squares.
The letters in wiki produce 3 valid words in the Scrabble and Words With Friends dictionaries. The word count by length is: 2 four-letter words and 1 two-letter word.