de and ed tie for the highest Scrabble score from de at 3 points. The top 2 of 2 words are shown here, with the full list organized by length below.
There are 2 two-letter words hiding in de: one comes from rearranging its letters, and de itself is already a playable word with no unscrambling required. No common everyday answer stands out among these two-letter results, so let the score decide: the highest-scoring words are de and ed, each worth 3 points in Scrabble.
The full list follows, sorted A to Z; every score reflects tile constraints and skips board bonuses.
de is in the NWL, the official Scrabble word list for North America, and in the Words With Friends dictionary, so it's playable exactly as it stands and needs no unscrambling.
Both totals match, because every tile in de carries the same value on a Scrabble board and on a Words With Friends board.
Dictionaries record one sense for de. Scrabble and Words With Friends score tiles and not meanings, so every sense below is worth the same 3 points on a Scrabble board:
de is one of two two-letter words the same letters produce. No arrangement of the same tiles scores higher in Scrabble, so playing de unchanged also takes the maximum points these letters offer.
The highest-scoring plays from these letters are de and ed, worth 3 points in Scrabble, and nothing else built from de earns more points in Scrabble. Words With Friends prices the same letters differently, so the top of the list changes on a Words With Friends board. Both scores count tile values only and exclude premium squares.
The letters in de produce 2 valid words in the Scrabble and Words With Friends dictionaries. The word count by length is: 2 two-letter words.