op and po tie for the highest Scrabble score from po at 4 points. The top 2 of 2 words are shown here, with the full list organized by length below.
There are 2 two-letter words hiding in po: one comes from rearranging its letters, and po itself is already a playable word with no unscrambling required. No common everyday answer stands out among these two-letter results, so let the score decide: the highest-scoring words are op and po, each worth 4 points in Scrabble.
po is in the NWL, the official Scrabble word list for North America, but not in the Words With Friends dictionary, so it plays in Scrabble only.
Dictionaries record four senses for po. Scrabble and Words With Friends score tiles and not meanings, so every sense below is worth the same 4 points on a Scrabble board:
po is one of two two-letter words the same letters produce. No arrangement of the same tiles scores higher in Scrabble, so playing po unchanged also takes the maximum points these letters offer.
The highest-scoring plays from these letters are op and po, worth 4 points in Scrabble, and nothing else built from po earns more points in Scrabble. Words With Friends prices the same letters differently, so the top of the list changes on a Words With Friends board. Both scores count tile values only and exclude premium squares.
The letters in po produce 2 valid words in the Scrabble and Words With Friends dictionaries. The word count by length is: 2 two-letter words.